Lake Region Medical
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Guidewire Platform Technologies Coating Technologies

Guidewire Platform Technologies

Lake Region Medical's platform of proprietary technologies deliver superior performance over conventional wire designs during cardiovascular, peripheral and neurovascular interventions.

Twister Logo

Twister Core Wire Technology

Optimize Performance in Complex Anatomy
TWISTER® Core Wire Technology is designed to optimize wire control in complex anatomy by providing a balance of support and kink-resistance.

A proprietary process stimulates micro lattice refinement of the core wire alloy to enable “hybrid” design characteristics. Product designs employing TWISTER® Technology will benefit from the support of a stainless steel alloy and enhanced shape-resistance properties necessary to deliver superior torque control during even the most challenging cases.

Features & Benefits
Improves resistance to wire deformation without compromising wire support or pushability
Enhances torque control (steering) by reducing core twisting during torsional transfer
Reduces tip shape loss during the procedure
to facilitate vessel selection and reselection


Twister Core Wire Technology Illustration
Technology Profile

Material: Stainless Steel
Description: Proprietary manufacturing process
Key Characteristics: Enhanced torque, kink-resistance, SST support equivalence, core wire durability
Microridge Logo

Microridge Core Wire Technology

Boost Torque Control
MICRORIDGE® extends guidewire control to the fingertips of physicians.

Industry-exclusive stabilizing ridge minimizes twisting in the distal core flat providing superior torque control (20% more torque when compared to non-ridged designs).  Additionally, MICRORIDGE® improves pushability by directing force to the distal tip minimizing tip prolapse.

Features & Benefits:
Delivers superior torque control (1:1 transmission) retention by minimizing twisting in the distal core flat
Improves guidewire delivery by minimizing tip prolapse and directing proximal “push” forces in the direction of the distal tip


Microridge Core Wire Technology Illustration

Technology Profile

Material: Stainless Steel
Description: Stabilizing ridge extending from distal core taper into flat
Key Characteristics: Enhanced torque (20% increase), improved distal tracking

TWISTER® and MICRORIDGE® are platform technologies used in BRIVANT® Guidewires manufactured by Lake Region Medical.
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Coating Technologies

Lake Region Medical has developed proprietary hydrophilic and hydrophobic coatings that serve a variety of clinical applications. Coatings are available on many Lake Region OEM guidewires but can also be added to existing designs to improve performance.

Aquarius Icon

Twister Core Wire Technology

Revolutionary Coating Technology
AQUARIUS® Direct-Coat Hydrophilic Coating utilizes a proprietary coating process to apply hydrophilic chemistry directly to the metal substrate of a device. Unlike products that require a polymer substrate for coating application, AQUARIUS® Hydrophilic Coating can be applied directly to existing stainless steel or nitinol designs to improve guidewire-to-catheter interface with low durometer, small french size catheters or crossing performance on interventional designs.

Features & Benefits
Improves guidewire-to-catheter interface
Conveniently applied to existing product design
More cost effective than polymer jacketed wires
Superior lubricity
510(k) registered on several OEM Guidewires
Transparent coating allows the addition of depth-indicator markings
Aquarius Hydrophilic Coating

Technology Profile

Material: Proprietary Formula
Type: Hydrophilic
Key Characteristics: Applied directly to metal substrate, lubricious, transparent

Aquarius Direct Coat Conventional PTFE Coating
AQUARIUS® Direct-Coated guidewires easily glide through low durometer catheters. Conventional PTFE-coated guidewires bind when withdrawn from low durometer, small french size catheters.
Lubrigreen Icon

Twister Core Wire Technology

Superior Performance from an Eco-Friendly Coating
LUBRIGREEN® utilizes a proprietary coating process to apply PTFE coating directly to bare wire prior to coil winding and guidewire assembly. This process produces a consistent and uniform coating, eliminating the inconsistencies and other drawbacks associated with spray-coating technologies. Lake Region’s new LUBRIGREEN® Pre-Coat PTFE has been reformulated to be more environmentally friendly while providing the same superior coating performance on which Lake Region has built its reputation. LUBRIGREEN® is 510(k) and CE Mark registered for a wide variety of diagnostic and interventional guidewire designs and clinical applications.

Features & Benefits:
Enhanced lubricity and durability
Consistent quality wire-to-wire
Reduces harmful Volatile Organic Compounds (VOC) and Perfluoctanoic (PFOA) materials
Reformulated coating qualifications
Meets and/or exceeds new EPA directives
Continuous source for environmentally safe PTFE coating
Lubrigreen PTFE Coating

Technology Profile

Material: PTFE
Type: Hydrophobic
Key Characteristics: Environmentally friendly, lubricious, durable

Lubrigreen Pre-Coat PTFE Spray-Coat PTFE
LUBRIGREEN® Pre-Coat PTFE Leading Competitive Spray-Coat PTFE
Excellence Icon

Twister Core Wire Technology

Consistent Coating for Reliable Performance
EXCELLENCE® Silicone Coating reduces friction between guidewires and interfacing devices resulting in a smooth guidewire-to-device interface. Lake Region's coating process produces a consistent, uniform coating surface ensuring the highest level of performance.

Features & Benefits:
Reduced surface friction facilitates improved guidewire-to-catheter interface
Application to existing product designs improves ease-of-use and expedites design time
510(k) registration provides quick market access
Transparent coating allows the addition of visual depth-indicator markings
Coating process provides a consistent, smooth coating surface from guidewire-to-guidewire
Excellence Hydrophobic Coating
Technology Profile

Material: Silicone
Type: Hydrophobic
Key Characteristics: Reduces friction, uniform, smooth, and consistent surface, transparent
Gemini Icon

Twister Core Wire Technology

A Biocompatible Coating with FDA Clearance
GEMINI™ Coating acts as an anticoagulant, releasing anti-thrombogenic agents to prevent the formation of thrombi and enhancing the body's natural mechanisms to break down clots that have already formed.

Features & Benefits:
Successfully addresses a wide range of clinical applications
Can be applied to any diagnostic guidewire configuration
Heparin Coating
Technology Profile

Key Characteristics: anticoagulant, antithrombogenic
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